Razvan Popa1,2,3, Diana Cenariu1, Ancuta Jurj4, Noemi Dirzu1, Sergiu Pasca5, Tiberiu Tat3, Daniela Ionescu6, Alexandru Irimie2
1Medfuture Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
1Department of Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
2Department of ICU, Ion Chiricuta Clinical Cancer Center, Cluj-Napoca, Romania
3Research Center for Functional Genomics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
4Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
5Department of ICU, Octavian Fodor Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania
Summary
Purpose: This study aimed to explore the influence of long non-coding ribonucleic acid (lncRNA) small nucleolar RNA host gene 1 (SNHG1) on the proliferation and apoptosis of gastric cancer cells.
Methods: Data from the TCGA ovarian cancer cohort were downloaded using cBioPortal. Ovarian cancer cell lines A2780 and A2780 cis were used in the study. Cases with documented sensitivity or resistance to platinum were selected, resulting in the inclusion of 287 patients with ovarian cancer. The mode of action of lidocaine in ovarian cancer cells was investigated. Data for both cell lines and selected concentrations suggested a slight inhibition of relative gene expression, but not statistically significant compared to the control group.
Conclusions: Local anesthetics administration has shown to be protective against tumor invasion and cell growth inhibition in various cancer cell lines. While the results suggest a higher lidocaine dose for patients, the study also demonstrated the potential to modify the biology of tumor cells.
Keywords: lidocaine, ovarian cancer, gynecologic malignancies, anesthesia.
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