Close Menu

    Subscribe to Updates

    Get the latest information from JBUON.

    What's Hot

    Two Cases of Pancreatic Metastases from Renal Cell Carcinoma and Review of the Literature

    April 17, 2025

    Exploration of Matrix Metalloproteinase-9 and Interleukin-8 in Breast Cancer Patients with No Lymph Node Involvement

    March 14, 2025

    Surgical Treatment of Right Atrial Metastasis of the Malignant Melanoma: A Case Report

    March 6, 2025
    Facebook X (Twitter) Instagram
    JBUONJBUON
    • How to Submit
    • Author Guidelines
    Facebook X (Twitter) Instagram
    SUBMIT
    • Home
    • Browse Issues
      • In Press
      • Current Issue
      • Archives
    • About Journal
      • Journal Information
      • Editorial Board
      • Bibliographic Listings
      • Editorial Policy
      • Ethics and Malpractice Statement
    • For Authors
      • How To Submit
      • Submit Article
      • Downloads
    • Contact
    JBUONJBUON
    Home»Issues»Volume 26, Issue 6»Vitamin C through upregulating SYNPO2 level suppresses the proliferation and migration of glioma cells
    Volume 26, Issue 6

    Vitamin C through upregulating SYNPO2 level suppresses the proliferation and migration of glioma cells

    November 30, 2021Updated:April 29, 20242 Mins Read
    Share
    Facebook Twitter Email

    Yishuo Zhu1, Xuan Wang2, Yujie Cui3, Jin Bai4, Junnian Zheng4, Yuechao Fan1

    1Department of Neurosurgery, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

    2China University of Mining and Technology, Xuzhou, China.

    3Medical Insurance Office, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

    4Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical University, Xuzhou, China.

    Summary

    Purpose: To demonstrate the progression of glioma influenced by Vitamin C (VC) and the potential molecular mechanism.

    Methods: The proliferative and migratory rates of U87 and U251 cells induced with 0, 50 and 100 µM VC were examined by CCK-8 and Transwell assay, respectively and the clinical significance of SYNPO2 in glioma patients was analyzed. Relative level of SYNPO2 in VC-induced glioma cells was detected. By intervening SYNPO2, the involvement of SYNPO2 in the anti-cancer role of VC in inhibiting glioma cell phenotypes was finally confirmed.

    Results: VC induction attenuated dose-dependently the proliferative and migratory potentials of glioma cells. A low level of SYNPO2 indicated poor prognosis of glioma. Protein and mRNA levels of SYNPO2 were upregulated in glioma cells induced with VC. The inhibitory effects of VC on proliferative and migratory potentials of glioma cells were partially reversed by knockdown of SYNPO2.

    Conclusion: VC blocks glioma cells to proliferate and migrate by upregulating SYNPO2.

    Key words: glioma, vitamin C, SYNPO2, proliferation, migration.

    Full Text: PDF

    Original Article
    Previous ArticleHigh-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with relapsed or refractory germ cell tumors
    Next Article Clinical application of patient derived xenograft mouse model in children with neuroblastoma

    Related Articles

    Exploration of Matrix Metalloproteinase-9 and Interleukin-8 in Breast Cancer Patients with No Lymph Node Involvement

    Volume 27, 2024

    Malignant Diseases as a Reason for Interventions by Emergency Medical Teams in Barajevo 2023

    Volume 27, 2024

    MicroRNA signatures landscape in renal cell carcinoma – related epithelial to mesenchymal transition

    Volume 26, Issue 6
    Don't Miss
    Volume 27, 2024

    Two Cases of Pancreatic Metastases from Renal Cell Carcinoma and Review of the Literature

    April 17, 2025

    Dimosthenis Chrysikos1, Spiros Delis2, Charina Triantopoulou2, Evgenia Charitaki2, Nikos Kokoroskos2, Nikolaos Taprantzis1*, Amir Shihada1, Konstantinos…

    Exploration of Matrix Metalloproteinase-9 and Interleukin-8 in Breast Cancer Patients with No Lymph Node Involvement

    March 14, 2025

    Surgical Treatment of Right Atrial Metastasis of the Malignant Melanoma: A Case Report

    March 6, 2025

    Abdominal Aortic Aneurysm and Radiation Therapy

    October 28, 2024
    Our Picks

    MicroRNA signatures landscape in renal cell carcinoma – related epithelial to mesenchymal transition

    December 1, 2021

    Chromosomal instability landscape in uveal melanoma

    December 1, 2021

    Biomarkers and common oral cancers: Clinical trial studies

    December 1, 2021

    Subscribe to Updates

    About Us
    About Us

    Journal of BUON (Print ISSN: 1107-0625, Electronic ISSN: 2241-6293) is an independent Open Access Journal, published by BAKIS Productions LTD, and appears exclusively on the internet. It is covered/indexed in Current Awareness in Biological Sciences (BIO-BASE), EMBASE/Excerpta Medica.
    We're accepting new manuscripts right now.

    Email Us: editorial_office@jbuon.com
    Contact: Available soon

    Editorial Picks

    MicroRNA signatures landscape in renal cell carcinoma – related epithelial to mesenchymal transition

    December 1, 2021

    Chromosomal instability landscape in uveal melanoma

    December 1, 2021

    Biomarkers and common oral cancers: Clinical trial studies

    December 1, 2021
    Get in Touch

    Editor-in-Chief
    Athanasios E. Athanasiou,
    Department of Medical Oncology,
    Metaxa Cancer Hospital, Botassi 51, 18537, Piraeus, Greece
    Editorial Office: editorial_office@jbuon.com

    Publishing support
    EManuscript Technologies
    # 9, First Floor, Vinnse Towers
    Wheeler Road Extension, St. Thomas Town, Bangalore 560 084, INDIA
    E: journals@emanuscript.in 
    W : www.emanuscript.in

     

    • Home
    • Author Guidelines
    • Site Map
    • Contact Us
    © 2025 JBUON Powered by EManuscript.

    Type above and press Enter to search. Press Esc to cancel.