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    Home»Issues»Volume 26, Issue 6»Corrected QT prolongation among chemotherapy – treated patients: A study of a Romanian center
    Volume 26, Issue 6

    Corrected QT prolongation among chemotherapy – treated patients: A study of a Romanian center

    November 30, 2021Updated:April 29, 20242 Mins Read
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    Cristina Crisan1, Calin Cainap1,3*, Anca Farcas3,4, Tiberiu Moldovan1, Eduard Radu1, Ovidiu Bochis1, Gabriela Morar-Bolba1, Adina Stan5*, Alina Bereanu6*, Catalin Vlad1,2, Patriciu Achimas1,2*, Simona Cainap2,3

    1“Prof. Dr. Ion Chiricuta” Oncology Institute of Cluj-Napoca, Romania.

    2Emergency County Hospital for Children, Pediatric Clinic no 2, Cluj-Napoca, Romania.

    3“Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania.

    4Emergency County Hospital, Internal Medicine no 1, Cluj-Napoca, Romania.

    5Department of Neuroscience, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania.

    6Faculty of Medicine, “Lucian Blaga”University of Sibiu, Sibiu, Romania.

    *These authors contributed equally to this article.

    Summary

    Purpose: Chemotherapy cardiotoxicity sometimes occurs as QTc prolongation, which may lead to ventricular arrhythmia. We assessed incidence of QTc prolongation among chemotherapy-treated patients.

    Methods: We enrolled 396 consecutive patients receiving chemotherapy in the Oncology Institute of Cluj-Napoca, Romania. 870 ECGs were performed at baseline and every 2 months, for 5 assessments, during 2016.

    Results: Most patients were diagnosed with gastro-intestinal tumors and received regimens containing more than one drug. No particular chemotherapy regimen was proved to significantly increase QTc. Maximum QTc was recorded after 4 months, when we also found the maximum incidence of increased QTc (>470ms), of 3.73% and of increased ΔQTc (>60ms), of 4%. Female gender was associated with a higher baseline QTc=421 ms, ± 26.9 (p=0.02). Age was linked to higher QTc and is also an independent variable predicting QTc prolongation (for QTc>480ms, p=0.02), as well as increase of ΔQTc (p<0.001). The number of prior chemotherapy lines correlates with baseline QTc (p<0.0001), with QTc prolongation after 2 months (p=0.01) and predicts higher ΔQTc after 2 months (p=0.01), although within normal range. There was no additive effect during all the 5 assessments.

    Conclusion: Our results confirm QTc prolongation with chemotherapy and a special attention should be paid to previously treated patients and to elderly patients.

    Key words: chemotherapy, cardiotoxicity, QTc prolongation.

    Full Text: PDF

    Original Article
    Previous ArticleChemotherapy in cholangiocarcinoma – experience of a tertiary cancer center from Romania
    Next Article Cytoreductive surgery and hyperthermic intrathoracic chemotherapy (HITHOC) in the treatment of primary and metastatic pleural malignancies – is extension of indications possible?

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