Volume 26, Issue 2 (March-April 2021)

OPINION ARTICLE

A farewell to Barcelona Clinic Liver Cancer (BCLC) classification for hepatocellular carcinoma
Dimitrios Moris; pp 298-302 (Pubmed Abstract, PDF)

SPECIAL ARTICLE

The “misfortune” of being a COVID-19 negative patient during the coronavirus pandemic
Nikolaos V. Michalopoulos, Zoe Petropoulou, Nikolaos Danias, Panagiotis Kokoropoulos, Pantelis Vassiliu, Nikolaos Arkadopoulos; pp 303-305 (Pubmed Abstract, PDF)

ORIGINAL ARTICLES

LUNG CANCER

Efficacy of EP chemotherapy followed by IP chemotherapy combined with radiotherapy in the treatment of extensive-stage small-cell lung cancer
Shiyang Kang, Chaopeng Ou, Ruifeng Xue, Weian Zeng, Jingxiu Huang, Yingjun Zhang, Dongtai Chen, Jielan Lai; pp 306-312 (Pubmed Abstract, PDF)

Thoracoscopic radical resection in the treatment of NSCLC patients (stage IIIA) after neoadjuvant chemotherapy
Liang Zhao, Lingling Zhang, Fang Gong, Jie Xu; pp 313-319 (Pubmed Abstract, PDF)

Chemotherapy combined with intermittent microwave ablation in the treatment of oligometastatic non-small cell lung cancer
Yuqing Shan, Xiangyuan Yin, Fanxia Lin, Chao Wang, Yunpeng Kong, Weijiang Yao; pp 320-327 (Pubmed Abstract, PDF)

Effects of postoperative adjuvant radiotherapy on stage IIIA-N2 non-small cell lung cancer and prognostic analysis
Tao Wang, Tao Jiang, Yong Han, Ailin Zhu, Shaowei Xin, Menghua Xue, Xiangbing Xin, Qiang Lu; pp 328-335 (Pubmed Abstract, PDF)

TUSC8 enhances cisplatin sensitivity of NSCLC cells through regulating VEGFA
Naiming Shi, Dengmei Feng, Yun Gu, Chengyuan Zheng, Miao Miao; pp 336-344 (Pubmed Abstract, PDF)

Long noncoding RNA NEAT1 aggravates sorafenib-resistance in non-small cell lung cancer via regulating miRNA-335/c-Met
Lin Mu, Hong Zhao, Yayun Yang, Runxu Song; pp 345-352 (Pubmed Abstract, PDF)

GRAIL inhibits the growth, migration and invasion of lung adenocarcinoma cells by modulating STAT3/C-MYC signaling pathways
Yue Zhu, Yuan Zhang, Wei Wei, Jifeng Feng; pp 353-358 (Pubmed Abstract, PDF)

CNS TUMORS

Biological functions of miRNA-188-5p/XRCC5 in the metastasis of glioma
Ning Leng, Weidong Zhou, Lei Jiang, Yongli Zhao, Mingyu Zhou, Shanshan Sun, Wen Nie; pp 359-365 (Pubmed Abstract, PDF)

High-dose methotrexate combined with rituximab improves the survival rate of patients with primary central nervous system lymphoma
Jing Fu, Xianjun Ma; pp 366-372 (Pubmed Abstract, PDF)

SPZ1 promotes glioma aggravation via targeting CXXC4
Cuili Di, Jinchuan Liang, Yong Wang, Guiliang Zhao, Yaqun Zhao; pp 373-379 (Pubmed Abstract, PDF)

EZH2-mediated long-chain non-coding RNA LINC00963 promotes proliferation and invasion of glioma cells through inhibiting p21 expression
Qimei Gai, Wei Guo, Junlian Liu; pp 380-387 (Pubmed Abstract, PDF)

NBR2 promotes the proliferation of glioma cells via inhibiting p15 expression
Jianjun Zhang, Hongsheng Jiang, Xuequan Feng, Liang Wang, Xinyu Yang; pp 388-394 (Pubmed Abstract, PDF)

Baicalein inhibits invasion and promotes apoptosis in glioma cells through the PI3K/Akt pathway
Yang Yang, Yuejiao Song, Qingbin Nie, Rong Tian, Jun Huang, Gengsheng Mao; pp 395-401 (Pubmed Abstract, PDF)

LIVER CANCER

RNA-binding protein RBM6 acts as a tumor suppressor gene to inhibit the progression of hepatocellular carcinoma
Zhihua Ye, Junkai Zhang, Yingyu Yang, Ying Wei, Lamei Li, Xinyi Wang; pp 402-408 (Pubmed Abstract, PDF)

Downregulated miRNA-22-3p promotes the progression and leads to poor prognosis of hepatocellular carcinoma through targeting CDKN2C
Demao Kong, Xia Wang, Xudong Wang, Zixuan Wang, Fa Wang; pp 409-417 (Pubmed Abstract, PDF)

miR-497 targets VEGF signal pathway to regulate proliferation, invasion and migration of hepatocellular carcinoma cells: a primary study using DEC-MRI
Tianyu Zhang, Guoxu Ding, Hao Wang, Haifeng Hu, Yuguang Wang, Hui Li, Hongwei Zhang, Li Wang, Wennan Lin, Liguo Hao, Bo Li, Chunlei Zheng, Youli Du, Lili Song; pp 418-428 (Pubmed Abstract, PDF)

Expression changes of miRNA-203 before and after transcatheter arterial chemoembolization in hepatocellular carcinoma patients and its clinical significance
Xianglu Li, Shizong Li, Xuehua Xing, Lin Wang; pp 429-434 (Pubmed Abstract, PDF)

Activation of human hepatic stellate cells enhances the metastatic ability of hepatocellular carcinoma cells via up-regulation of interleukin-1β
Bianqiao Cheng, Zhiteng Huang, Linlin Wu, Yanchen Lin, Weiguo Lin, Qi Zhu; pp 435-443 (Pubmed Abstract, PDF)

BREAST CANCER

The m6A methyltransferase METTL3 promotes the stemness and malignant progression of breast cancer by mediating m6A modification on SOX2
Jiping Xie, Jinling Ba, Min Zhang, Yi Wan, Zeyu Jin, Yonqiang Yao; pp 444-449 (Pubmed Abstract, PDF)

MicroRNA-224 modulates chemosensitivity of breast cancer cells to docetaxel by apoptosis inhibitor 5
Junying Zhang, Ya Lu, Ye Zhang, Yan Chen, Wenbo Zhu, Hangju Zhu, Jianzhong Wu, Jinhai Tang; pp 450-458 (Pubmed Abstract, PDF)

MIR31HG regulates the proliferation, migration and invasion of breast cancer by regulating the expression of POLDIP2
Chunxia Xin, Xiang Bi, Chun Xiao, Liangliang Dong; pp 459-465 (Pubmed Abstract, PDF)

High Ki67 as negative predictor for response to concurrent radiotherapy plus Capecitabine in chemo-resistant advanced breast cancer
Danijela Trokic, Goran Marosevic, Vlado Simeunovic, Stanislava Lekic, Bozana Babic, Zdenka Gojkovic; pp 466-474 (Pubmed Abstract, PDF)

Evaluation of Cyclin D1 expression by western blotting methods and immunohistochemistry in breast cancer patients
Sandra Radenkovic, Gordana Konjevic, Marina Nikitovic, Suzana Stojanovic-Rundic, Vesna Plesinac-Karapandzic, Marijana Milovic-Kovacevic, Vladimir Jurisic; pp 475-482 (Pubmed Abstract, PDF)

GASTRIC CANCER

Expression of miR-614 in gastric cancer and its effect on invasion and proliferation of gastric cancer cells HGC-27
Fengneng Jing, Hong Li, Qiuping Gao; pp 483-489 (Pubmed Abstract, PDF)

Effects of laparoscopic-assisted gastrectomy on elderly patients with gastric cancer
Kai Xu, Jiadi Xing, Yingcong Fan, Ming Cui, Chenghai Zhang, Hong Yang, Zhendan Yao, Nan Zhang, Lei Chen, Maoxing Liu, Fei Tan, Pin Gao, Xiangqian Su; pp 490-498 (Pubmed Abstract, PDF)

NTF4 stimulates the progression of gastric cancer via regulating FOXL1
Jiejie Jin, Lei Wang, Yanong Wang; pp 499-505 (Pubmed Abstract, PDF)

LINC00202 attenuates the progression of gastric cancer via suppressing expression level of KLF2
Qin Xu, Song Qiao, Lin Liu, Jing Xu, Lifen Yang, Xiuying Chen, Ludi Yang, Biao Yao; pp 506-512 (Pubmed Abstract, PDF)

COLORECTAL CANCER

Prognostic and immunomodulatory effects of PIM1 in colorectal carcinoma
Yun Zhou, Yongning Zhou, Shixiong Liu, Jing Wang, Rui Ji, Xiang Yan; pp 513-520 (Pubmed Abstract, PDF)

Comparative study of Overlap anastomosis and traditional anastomosis in total laparoscopic radical resection of left colon cancer
Yi Zhang, Qian Yao, Zhulong Hu, Xia Li, Dashuang Gao, Changkuo Liu; pp 521-527 (Pubmed Abstract, PDF)

A novel role of miR-326 in colorectal carcinoma by regulating E2F1 expression
Zengtao Bao, Shanting Gao, Qiang Tang, Baoming Zhang, Wenchao Shi, Qingshui Tian; pp 528-535 (Pubmed Abstract, PDF)

Decreased ERβ expression and high cyclin D1 expression may predict early CRC recurrence in high-risk Duke’s B and Duke’s C stage
Aleksandra Babic, Nenad Miladinovic, Jelena Milin-Lazovic, Sanja Milenkovic;p 536-543 (Pubmed Abstract, PDF)

GYNECOLOGIC CANCERS

CDCA5 is negatively regulated by miR-326 and boosts ovarian cancer progression
Aihua Gao, Yanrong Hu, Weipei Zhu; pp 544-552 (Pubmed Abstract, PDF)

Clinical efficacy analysis of Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with Paclitaxel-Cisplatin Chemotherapy in patients with Advanced Ovarian Cancer
Yue Gao, Yafei Hao, Yuanyuan Jia; pp 553-560 (Pubmed Abstract, PDF)

Efficacy of Postoperative Radiotherapy Combined with TC Chemotherapy Regimens in the Treatment of High-risk Early-Stage Endometrial Cancer
Ting Kang, Ningning Liu, Xiaodong Sun, Min Liu; pp 561-568 (Pubmed Abstract, PDF)

HEMATOLOGIC MALIGNANCIES

Clinical significance of PD-1 and PD-L1 molecules in patients with diffuse large B cell lymphoma, not otherwise specified: Correlation with clinical and pathological findings
Stamatis Karakatsanis, Stamatis Papadatos, Nikolaos Syrigos, Leonidas Marinos, Evi Pouliou, Asimina Papanikolaou; pp 569-579 (Pubmed Abstract, PDF)

MiR-223 Suppresses Proliferation and Promotes Apoptosis of Diffuse Large B-Cell Lymphoma Cells Through Lmo2 and MAPK Signaling Pathway
Yongmei Zhang, Jie Zhang; pp 580-586 (Pubmed Abstract, PDF)

Correlation between lncRNA H19 rs2839698 polymorphism and susceptibility to NK / T cell lymphoma in Chinese population
Jiangzhao Zhang, Min Liu, Yan Liang, Min Zhang, Zhiping Huang; pp 587-591 (Pubmed Abstract, PDF)

OSTEOSARCOMA

Expression level of PLAC1 in osteosarcoma patients and its regulatory effect on the development of osteosarcoma
Yifan Yu, Yong Xu, Wei Cai, Wenshan Zuo; pp 592-598 (Pubmed Abstract, PDF)

MiR-505-5p inhibits proliferation and promotes apoptosis of osteosarcoma cells via regulating RASSF8 expression
Tao Wang , Huayu Zhang, Huiwang Wang, Cheng Chang, Fei Huang, Liansuo Zhang; pp 599-605 (Pubmed Abstract, PDF)

HEAD & NECK CANCERS

FTI-277 and GGTI-289 induce apoptosis via inhibition of the Ras/ERK and Ras/mTOR pathway in head and neck carcinoma HEp-2 and HSC-3 cells
Keisuke Tateishi, Masanobu Tsubaki, Tomoya Takeda, Yuuta Yamatomo, Motohiro Imano, Takao Satou, Shozo Nishida; pp 606-612 (Pubmed Abstract, PDF)

THYROID CANCER

Apatinib strengthens the anti-tumor effect of cisplatin in thyroid carcinoma through downregulating VEGFR2
Ying Hu, Ning Zhou, Ru Wang; pp 613-619 (Pubmed Abstract, PDF)

MISCELLANEOUS

Quality of life and tolerance to mental pain scale in cancer patients subjected to bone scan 
Chrissa Sioka, Paraskevi Platari, Athanasios Papadopoulos, Konstantinos Papadimitropoulos, Georgia Zafeiri, Vasilios Ragos, Evangelos Tsiambas, Efthymios Kyrodimos, Petros Argitis, Petros Petrikis, Andreas Fotopoulos; pp 620-625 (Pubmed Abstract, PDF)

The role of melatonin in preventing radiation-induced intestinal injury
Orhan Sezen, Burak Erdemci, Muhammet Calik, Mehmet Koc; pp 626-633 (Pubmed Abstract, PDF)

LETTERS TO THE EDITOR

Metastatic occult breast carcinoma to gallbladder initially presenting as acute cholecystitis
Kadri Altundag; p 634 (Pubmed Abstract, PDF)

EGFR mutational landscape in nasopharyngeal carcinoma
Arezina Manoli, Spyros Katsinis, Dimitrios Roukas, Evangelos Tsiambas; p 634 (Pubmed Abstract, PDF)

Management of multifocal HER-2 positive and hormone receptor negative microinvasive (T1mic) breast carcinoma; To treat or not to treat ?
Kadri Altundag; p 635 (Pubmed Abstract, PDF)

Impact of BRAF mutations in nasopharyngeal carcinoma
Spyros Katsinis, Arezina Manoli, Sotirios Papouliakos, Evangelos Tsiambas; p 636 (Pubmed Abstract, PDF)

Isolated left pleural metastasis after 31 years of disease-free interval in early-stage breast cancer patient: the latest recurrence in the literature
Kadri Altundag; p 636 (Pubmed Abstract, PDF)

Atezolizumab plus bevacizumab for advanced, unresectable hepatocellular carcinoma
Diamantis I. Tsilimigras, Dimitrios Moris; p 637 (Pubmed Abstract, PDF)

Breast cancer diagnosis at earlier age in left‐handed patients: Still debatable issue?
Kadri Altundag; pp 638 (Pubmed Abstract, PDF)

RETRACTIONS

Retraction Note to: In vitro and in vivo human gastric cancer inhibition by Trifolirhizin is facilitated via autophagy, mitochondrial mediated programmed cell death, G2/M phase cell cycle arrest and inhibition of m-TOR/PI3K/AKT signalling pathway
Ke Zhang, Weidong Liu, Zhan Qu, Qin Liu, Jie Chen, Ran Tao, Youming Deng, Yu Zhang; p 639 (Pubmed Abstract, PDF)

Retraction Note to: Totarol, a natural diterpenoid, induces selective antitumor activity in SGC-7901 human gastric carcinoma cells by triggering apoptosis, cell cycle disruption and suppression of cancer cell migration
Tong Xu, Lunhua Huang, Zhiqiang Liu, Dongwen Ma, Guowei Zhang, Xiaofei Ning, Xinyang Lu, Hongsheng Liu, Biao Jiang; p 640 (Pubmed Abstract, PDF)

Retraction Note to: Anticancer activity of fisetin against the human osteosarcoma cell lines involves G2/M cell cycle arrest, mitochondrial apoptosis and inhibition of cell migration and invasion
Chunyang Xing, Yuzhu Zhang, Rong Su, Ronghuan Wu; pp 641 (Pubmed Abstract, PDF)

Retraction Note to: Sulforaphane exerts anticancer effects on human liver cancer cells via induction of apoptosis and inhibition of migration and invasion by targeting MAPK7 signalling pathway
Bo Huang, Shixiong Lei, Dong Wang, Yibo Sun, Jikai Yin; pp 642 (Pubmed Abstract, PDF)

EXPRESSION OF CONCERN

Tormentic acid induces anticancer effects in cisplatin-resistant human cervical cancer cells mediated via cell cycle arrest, ROS production, and targeting mTOR/PI3K/AKT signalling pathway
Jinrong Wu, Ning Wang, Gang Jin, Lili Xue; p 643 (Pubmed Abstract, PDF)

Bismahanine exerts anticancer cells effects on human cervical cancer cells by inhibition of growth, migration and invasion via suppression of NF-kB signalling pathway
Limin Yu, Yan Sun, Jing Su, Xiang Li; p 644 (Pubmed Abstract, PDF)

Antitumor effects of flavokawain-B flavonoid in gemcitabine-resistant lung cancer cells are mediated via mitochondrial-mediated apoptosis, ROS production, cell migration and cell invasion inhibition and blocking of PI3K/AKT Signaling pathway
Rong Hua, Yaofei Pei, Haiyong Gu, Yifeng Sun, Yi He; p 645 (Pubmed Abstract, PDF)

Heptaphylline suppresses the proliferation and migration of human bladder cancer cells via induction of intrinsic apoptosis, autophagy and inhibition of β-catenin signalling pathway
An Xu, Gang-Gang Yang, Yu Zhang, Shu-Tian Zhao; p 646 (Pubmed Abstract, PDF)

Inhibition of cancer cell growth in cisplatin-resistant human oral cancer cells by withaferin-A is mediated via both apoptosis and autophagic cell death, endogenous ROS production, G2/M phase cell cycle arrest and by targeting MAPK/RAS/RAF signalling pathway
Xuelian Yin, Guang Yang, Dongjie Ma, Zhejun Su; p 647 (Pubmed Abstract, PDF)

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